Age not FSH determines IVF aneuploidy risk

Analyzing the influence of age and basal levels of follicle stimulating hormone on the risk for aneuploidy in women undergoing IVF.

The risk of embryonic aneuploidy in women undergoing IVF is significantly influenced by age but not by follicle stimulating hormone (FSH) levels, say scientists.

Researchers from the Lister Fertility Clinic in London, UK, note the decline in fecundity seen in women of advanced maternal age “is attributed to reduction of ovarian reserve and deterioration of oocyte quality.

Journal abstract

Full article: http://www.spainfertility.com/2008/08/29/age-not-fsh-determines-ivf-aneuploidy-risk/

From: SpainFertility: the destination for fertility tourists

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Study on high FSH and aneuploidy

Relationship between women's age and basal follicle-stimulating hormone levels with aneuploidy risk in in vitro fertilization treatment

Objective
To assess the relationship of age and basal FSH level to the genetic quality of the embryo and the association with IVF treatment outcome.

Patient(s)
One hundred fifty-one women who underwent IVF treatment cycles in conjunction with preimplantation genetic diagnosis for aneuploidy screening before fresh embryo transfer, between July 2003 and July 2005.

Intervention(s)
Basal FSH levels (days 2–4) were determined at an earlier cycle, and women were divided into two groups: high basal FSH (greater than or equal to 10 IU/L) and low basal FSH (less than 10 IU/L). Chromosome analysis was performed on a single blastomere by using fluorescence in situ hybridization.

Main Outcome Measure(s)
Percentage of aneuploid embryos.

Result(s)
The percentage of aneuploid embryos was not statistically significantly different between the high– (50.0%, n = 32) and low– (50.2%, n = 119) basal FSH groups. However, the percentage of aneuploid embryos was statistically significantly higher (56.2%, n = 109) for women aged greater than or equalto 38 years, as compared with women less than 38 years of age (37.5%, n = 42), independent of basal FSH levels.

Conclusion(s)
Elevated basal FSH levels reflect lower ovarian reserve but have no association with genetic quality of embryos. The percentage of aneuploid embryos is increased with advanced maternal age.

Source: http://www.fertstert.org/article/PIIS0015028207014185/abstract?rss=yes

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Novel IVF test may cut risk of twins, triplets

Washington , Dec 31 (ANI): A revolutionary in vitro fertilisation (IVF) test, which may slash the risk of multiple births while increasing the chances of pregnancy, will soon be offered to British couples.

The pre-implantation genetic screening (PGS) test aims to boost the success rates when only a single embryo is transplanted into the womb, so that multiple pregnancies may be prevented.

However, a different form of PGS is already licensed to detect chromosomal abnormalities that cause embryos to fail, but only for older patients or those with a history of miscarriage or IVF failure.

The PGS test is also controversial with almost no proof to establish the fact that it aids in conception. It was recently reported that the British Fertility Society had recommended that its members stop using it.

In the more advanced version of PGS, around 50-100 women will be recruited. It will be conducted by Dagan Wells, of the Reprogenetics UK clinic and the University of Oxford .

Wells is seeking permission from the fertility regulator for the test, with a view to identifying the best embryo produced by young IVF patients aged under 35 having good prognosis.

If successful, the trial may influence many more infertile couples into opting for single embryos, corresponding to the Human Fertilisation and Embryology Authority's strategy to cut IVF twin and triplet births from one in four to one in ten.

At present, almost 90 per cent of IVF cycles use two embryos, because clinics and couples fear that the pregnancy rates may decline by using just one embryo.

I think this is going to be a wonderful thing for moving towards single embryo transfer. If you're only going to put back one embryo, its more important than ever that you get the best one, and that is what we think this test can do, Times Online quoted Dr Wells as saying.

The new technique has been used on three women in America and two of them are now pregnant.

The PGS aims to identify chromosomal abnormalities called aneuploidies, which affect up to two thirds of embryos and cause implantation failure or miscarriage.

It is dependent on three new technologies, and comes with improved accuracy and lower risk.

Source: http://www.thaindian.com/newsportal/health/novel-ivf-test-may-cut-risk-of-twins-triplets_10010842.html

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