Cobalamin (Vitamin B12) Supplementation for Infertile Couples?

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In a cross-sectional study involving 171 couples visiting an infertility clinic, results indicate a high prevalence of cobalamin deficiency.

Mean cobalamin levels were 259.2 pg/mL in men and 275.1 pg/mL in women, with 35.5% of men and 23.3% of women showing cobalamin deficiency.

Additionally, 39% of all men with an abnormal semen analysis showed cobalamin deficiency.

Thus, the authors conclude, "This study questions whether higher rates of male infertility in Israel are partially ascribable to cobalamin deficiency. Recommendation for supplementation in both males and females to achieve high-normal levels of cobalamin would be prudent."

Reference: "Prevalence of low serum cobalamin in infertile couples," Pront R, Elstein D, et al, Andrologia, 2009; 41(1): 46-50. (Address: Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel). Source

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